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Dr. John Marlier

Professor Emeritus


Organic Chemistry


B.S. Chemistry -University of Wisconsin, Stevens Point - 1972
PhD Chemistry - University of Wisconsin, Madison - 1978
NIH Postdoctoral Fellow (Enzymology)
The Pennsylvania State University 1978 - 1981


Research Interests:

Mechanistic studies of both organic and enzyme-catalyzed reactions of esters, amides and thioesters. The experimental methods include:

  • Kinetics
  • Kinetic isotope effects (both hydrogen and heavy-atom)
  • Isotope exchange via 13C-NMR and mass spectrometry
  • pKa determination via 15N-NMR

Five Most Recent Publications:

  1. Fogle, E.J.; Marlier, J. F.; Stillman, A.; Gao, X.; Rao, Y.; Robins, L. I.  An Investigation into Butyrycholinesterase-catalzyed Hydrolysis of Formylthiocholine Using Heavy Atom Kinetic Isotope Effects.   Bioorg. Chem.  2016, 65, 57-60.
  2. Robins, L.I.; Fogle, E.J.; Marlier, J.F.  Mechanistic Investigations of the Hydrolysis of Amides, Oxoesters, and Thioesters via Kinetic Isotope Effects and Isotope Exchange. Biochemica et Biophysica. Acta, 2015, 1854, 1756-1767.
  3. Marlier, J.F.; Fogle, E.J.; Redman, R. L.; Stillman, A. D.; Denison, M. A.; Robins L. I.  A Mechanistic Study of Thioester Hydrolysis with Heavy Atom Kinetic Isotope Effects. J. Org. Chem. 2015, 80, 1905.
  4. Robins, L.I.; Meisenheimer, K.M.; Fogle, E.J.; Chaplin, C.A.; Redman, R. L.; Vacca, J.T.; Tellier, M. R.; Collins, B. R.; Duong, D.H.; Schulz, K.; Marlier, J.F. A Kinetic Isotope Effect and Isotope Exchange Study of the Nonenzymatic and Butyrylcholineserase-catalyzed Thioester Hydrolysis. J. Org. Chem., 2013, 78,12029-12039.
  5. Marlier, J. F.; Cleland, W. W.; Zeczycki, T.N.  Oxamate is an Alternative Substrate for Pyruvate Carboxylase from Rhizobium etli. Biochemistry, 2013, 52, 2888-2894.


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